Mitochondrial aldehyde dehydrogenase (ALDH2) rescues cardiac contractile dysfunction in an APP/PS1 murine model of Alzheimer’s disease via inhibition of ACSL4-dependent ferroptosis
Zhiyun Zhu, Yandong Liu, Yan Gong, Jin Wei, Elena Topchiy, Subat Turdi, Yuefeng Gao, Bruce Culver, Shuyi Wang, Wei Ge, Wenliang Zha, Jun Ren, Zhaohui Pei, Xing Qin
Topics & Concepts
ALDH2Lipid peroxidationOxidative stressTransgeneGenetically modified mouseEndocrinologyInternal medicineAldehyde dehydrogenaseBiologyChemistryPharmacologyBiochemistryMedicineEnzymeGeneFerroptosis and cancer prognosisEndoplasmic Reticulum Stress and DiseaseGenomics, phytochemicals, and oxidative stress