Expedition to Phenanthrene Nucleus: A Two‐decade Research on Bench
Stephy Elza John, Ramya Tokala, Venkata Rao Kaki, Nagula Shankaraiah
Abstract
Abstract The phenanthrene nucleus is extensively found in diverse natural products and its versatility is not just limited to pharmaceutically beneficial molecules but has proved efficient in the development and synthesis of dyes, plastics, pesticides and explosives. Such a relevant nucleus has attracted researchers to probe into the construction of phenanthrene nucleus. The past two decades have witnessed continuous efforts in this direction with the exploration of various synthetic strategies enabling access to the privileged core. The review focuses on bringing the advances made in 20 years in these synthetic protocols and the mechanism involved in the generation of phenanthrene and its derivatives under one roof. In addition, it also provides a comparative study of the diverse approaches and vivid reactions employed for phenanthrene synthesis providing a better understanding and creating newer ideas towards the development of new chemical entities (NCEs).