Design and synthesis of mycobacterial pks13 inhibitors: Conformationally rigid tetracyclic molecules
Wei Zhang, Ling-ling Liu, Shichun Lun, Shuang-Shuang Wang, Shiqi Xiao, Hendra Gunosewoyo, Fan Yang, Jie Tang, William R. Bishai, Li-Fang Yu
Topics & Concepts
ChemistryStereochemistryThioesterasePolyketide synthaseMycobacterium tuberculosisSelectivityBenzofuranIndole testStructure–activity relationshipPolyketideEnzymeBiochemistryTuberculosisIn vitroBiosynthesisPathologyCatalysisMedicineMicrobial Natural Products and BiosynthesisCancer therapeutics and mechanismsCarbohydrate Chemistry and Synthesis