Self-Assembling Nanoparticle Vaccines Displaying the Receptor Binding Domain of SARS-CoV-2 Elicit Robust Protective Immune Responses in Rhesus Monkeys
Heng Li, Lei Guo, Huiwen Zheng, Jing Li, Xin Zhao, Jiaqi Li, Yan Liang, Fengmei Yang, Yurong Zhao, Jinling Yang, Mengyi Xue, Yuanyuan Zuo, Jian Zhou, Yanli Chen, Zening Yang, Yanyan Li, Weihua Jin, Haijing Shi, Zhanlong He, Qihan Li, Longding Liu
Abstract
CCID50 SARS-CoV-2 virus, compared with unimmunized control animals, virus replication in the vaccine-immunized rhesus monkeys was significantly inhibited, and respiratory pathology observations also showed only slight pathological damage. These analyses will benefit the immunization program of the RBD-ferritin nanoparticle vaccine in the clinical trial design and the platform construction to present a specific antigen domain in the self-assembling nanoparticle in a short time to harvest stable, safe, and effective vaccine candidates for new SARS-CoV-2 isolates.