INTS11 regulates hematopoiesis by promoting PRC2 function
Peng Zhang, Pinpin Sui, Shi Chen, Ying Guo, Ying Li, Guo Ge, Ganqian Zhu, Hui Yang, Cody M. Rogers, Patrick Sung, Stephen D. Nimer, Mingjiang Xu, Feng‐Chun Yang
Abstract
-deficient HSPCs restores the levels of PRC2 and H3K27me3 as well as HSPC functions. Collectively, our data demonstrate that INTS11 is an essential regulator of HSPC homeostasis through the INTS11-PRC2 axis.
Topics & Concepts
PRC2Cell biologyHistone H3HaematopoiesisProgenitor cellBiologyEpigeneticsEnhancerRegulatorPolycomb-group proteinsEZH2Stem cellGeneticsGeneTranscription factorRepressorRNA modifications and cancerRNA Research and SplicingEpigenetics and DNA Methylation