Design, synthesis, and biological evaluation of novel benzo[b]thiophene-diaryl urea derivatives as potential anticancer agents
Omid Zarei, Fereshteh Azimian, Maryam Hamzeh‐Mivehroud, Javid Shahbazi Mojarrad, Salar Hemmati, Siavoush Dastmalchi
Topics & Concepts
ChemistryPharmacophorePropidium iodideCell cycleDAPIApoptosisThiopheneSorafenibFlow cytometryCell cycle checkpointStereochemistryChalconeCell cultureA549 cellCombinatorial chemistryBiochemistryCancer researchMolecular biologyProgrammed cell deathOrganic chemistryBiologyGeneticsHepatocellular carcinomaSynthesis and biological activityEnzyme function and inhibitionBioactive Compounds and Antitumor Agents