Covalent Proteomimetic Inhibitor of the Bacterial FtsQB Divisome Complex
Felix M. Paulussen, Gina K. Schouten, Carolin Moertl, Jolanda Verheul, Irma Hoekstra, Gregory M. Koningstein, George H. Hutchins, Aslihan Alkir, Rosa A. Luirink, Daan P. Geerke, Peter van Ulsen, Tanneke den Blaauwen, Joen Luirink, Tom N. Grossmann
Abstract
strain. This first-in-class inhibitor of a divisome protein-protein interaction highlights the potential of proteomimetic molecules as inhibitors of challenging targets. In particular, the covalent mode-of-action can serve as an inspiration for future antibiotics that target protein-protein interactions.
Topics & Concepts
Periplasmic spaceChemistryEscherichia coliAntibioticsCovalent bondBiogenesisMicrobiologyCell biologyBiochemistryBiologyGeneOrganic chemistryBacteriophages and microbial interactionsRNA and protein synthesis mechanismsChemical Synthesis and Analysis