CRL4 <sup>DCAF1/VprBP</sup> E3 ubiquitin ligase controls ribosome biogenesis, cell proliferation, and development
Xiaoran Han, Naoya Sasaki, Sarah Jackson, Pu Wang, Zhijun Li, Matthew D. Smith, Ling Xie, Xian Chen, Yanping Zhang, William F. Marzluff, Yue Xiong
Abstract
loss increases free RPL11, resulting in L11-MDM2 association and p53 activation. Cumulatively, these results reveal a critical function for DCAF1 in ribosome biogenesis and define a molecular basis of DCAF1 function in cell proliferation and development.
Topics & Concepts
Ubiquitin ligaseRibosome biogenesisRibosomeCell biologyCell growthBiologyBiogenesisTranslation (biology)UbiquitinUbiquitin-Protein LigasesProtein biosynthesisGeneticsMessenger RNARNAGeneRNA modifications and cancerUbiquitin and proteasome pathwaysPeptidase Inhibition and Analysis