A two-photon lysosome-targeted probe for endogenous formaldehyde in living cells
Ting Cao, Ma Hong
Abstract
was at ∼540 nm, with a slight blue shift (∼528 nm) in response to FA, while the green fluorescence intensity increased. The probe exhibits excellent selectivity for FA among other biological interference species and a fast response time for FA. It is worth mentioning that the probe successfully imaged endogenous FA in cells in two-photon mode, making the probe an effective research tool in the biomedical field to study diseases related to abnormal FA expression.
Topics & Concepts
LysosomeEndogenyFormaldehydeChemistryTwo-photon excitation microscopyBiophysicsCell biologyNanotechnologyMaterials scienceBiologyBiochemistryPhysicsFluorescenceOpticsEnzymeRedox biology and oxidative stressAntioxidant Activity and Oxidative StressFree Radicals and Antioxidants