Rh(<scp>iii</scp>)-catalyzed [4 + 1] cyclization of aryl substituted pyrazoles with cyclopropanols <i>via</i> C–H activation
Wenxi Chen, Yan Mao, Min Wang, Fei Ling, Changchang Li, Zhangpei Chen, Jinzhong Yao
Abstract
]isoindoles is described. The reaction features good functional group compatibility and a broad substrate scope with respect to both cyclization components with up to 84% yields. Mechanistic studies indicated that the C-H cleavage might be the rate-determining step in this transformation.
Topics & Concepts
ChemistryRhodiumArylCatalysisMedicinal chemistryBond cleavageCombinatorial chemistryStereochemistryCleavage (geology)Functional groupOrganic chemistryPolymerAlkylEngineeringGeotechnical engineeringFracture (geology)Catalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsCatalytic Alkyne Reactions