Mitochondrial Imbalance of <i>Trypanosoma cruzi</i> Induced by the Marine Alkaloid 6-Bromo-2′-de-<i>N</i>-Methylaplysinopsin
Maiara M. Romanelli, Maiara Amaral, Fernanda Thevenard, Lucas Monteiro Santa Cruz, Luís Octávio Regasini, Álvaro Esteves Migotto, João Henrique G. Lago, André G. Tempone
Abstract
, suggesting a different mechanism from benznidazole. In silico pharmacokinetic-pharmacodynamic (PKPD) parameters suggested a drug-likeness property, supporting the promising usefulness of this compound as a new hit for optimizations.
Topics & Concepts
Trypanosoma cruziChagas diseaseAlkaloidBiologyChemistryVirologyBotanyParasite hostingComputer scienceWorld Wide WebTrypanosoma species research and implicationsResearch on Leishmaniasis StudiesBiochemical and Molecular Research