Photoredox-mediated hydroalkylation and hydroarylation of functionalized olefins for DNA-encoded library synthesis
Shorouk O. Badir, Alexander Lipp, Matthias Krumb, María Jesús Cabrera‐Afonso, Lisa Marie Kammer, Victoria E. Wu, Minxue Huang, Adam Csakai, Lisa A. Marcaurelle, Gary A. Molander
Abstract
protocol, the coupling of functionalized, electronically unbiased olefins is achieved under air and within minutes of blue light irradiation through the intermediacy of reactive (hetero)aryl radical species with full retention of the DNA tag integrity. Notably, these processes operate under mild reaction conditions, furnishing complex structural scaffolds with a high density of pendant functional groups.
Topics & Concepts
DNACombinatorial chemistryChemistryIdentification (biology)Computational biologyBiologyBiochemistryBotanyChemical Synthesis and AnalysisFluorine in Organic ChemistrySynthesis and Catalytic Reactions