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Inhibition of c-Jun N-terminal kinase signaling increased apoptosis and prevented the emergence of ALK-TKI-tolerant cells in ALK-rearranged non-small cell lung cancer

Keiko Tanimura, Tadaaki Yamada, Mano Horinaka, Yuki Katayama, Sarina Fukui, Kenji Morimoto, Takayuki Nakano, Shinsaku Tokuda, Yoshie Morimoto, Masahiro Iwasaku, Yoshiko Kaneko, Junji Uchino, Kazue Yoneda, Seiji Yano, Toshiyuki Sakai, Koichi Takayama

2021Cancer Letters21 citationsDOI

Topics & Concepts

Anaplastic lymphoma kinaseAlectinibCrizotinibCancer researchALK inhibitorc-junTyrosine kinaseLung cancerKinaseCeritinibMedicineBiologyPharmacologySignal transductionInternal medicineCell biologyBiochemistryTranscription factorGeneMalignant pleural effusionLung Cancer Treatments and MutationsCancer Mechanisms and TherapyCancer therapeutics and mechanisms
Inhibition of c-Jun N-terminal kinase signaling increased apoptosis and prevented the emergence of ALK-TKI-tolerant cells in ALK-rearranged non-small cell lung cancer | Litcius