Pracinostat combined with azacitidine in newly diagnosed adult acute myeloid leukemia (AML) patients unfit for standard induction chemotherapy: PRIMULA phase III study
Guillermo Garcia‐Manero, Maciej Kaźmierczak, Agnieszka Wierzbowska, Chun Yew Fong, Michael Keng, Gianluca Ballinari, F. Scarci, Lionel Adès
Topics & Concepts
MedicineAzacitidineInternal medicineOncologyInduction chemotherapyMyeloid leukemiaChemotherapyHypomethylating agentInterim analysisPlaceboClinical endpointPhases of clinical researchClinical trialPathologyBiologyDNA methylationBiochemistryGene expressionAlternative medicineGeneHistone Deacetylase Inhibitors ResearchAcute Myeloid Leukemia ResearchProtein Degradation and Inhibitors