Saponins as cytotoxic agents: an update (2010–2018). Part I—steroidal saponins
Danuta Sobolewska, Agnieszka Galanty, Karolina Grabowska, Justyna Makowska‐Wąs, Dagmara Wróbel‐Biedrawa, Irma Podolak
Abstract
Abstract Steroidal saponins are a group of glycosides widely distributed among monocotyledonous families. They exert a wide spectrum of biological effects including cytotoxic and antitumor properties which are the most studied. This review is an update of our previous paper— Saponins as cytotoxic agents (Podolak et al. in Phytochem Rev 9:425–474, 2010) and covers studies that were since published (2010–2018). In this paper we refer to steroidal saponins presenting results of cytotoxicity studies, mechanisms of action and structure–activity relationships.
Topics & Concepts
Cytotoxic T cellCytotoxicitySaponinGlycosideChemistryStereochemistryBroad spectrumPharmacologyBiologyComputational biologyCombinatorial chemistryBiochemistryMedicineIn vitroPathologyAlternative medicineNatural product bioactivities and synthesisPhytochemical Studies and BioactivitiesPhytochemistry and Bioactive Compounds