Pomegranate supplementation alleviates dyslipidemia and the onset of non-alcoholic fatty liver disease in Wistar rats by shifting microbiota and producing urolithin-like microbial metabolites
Guadalupe Sánchez-Terrón, Remigio Martínez, David Morcuende, Víctor Caballero, Mario Estévez
Abstract
= 6). Body weight and energy intake were registered weekly. P supplementation decreased fat depots, counteracted the dyslipidemia caused by F and improved markers of liver injury including steatosis. The study of the microbiota by metagenomics and urine by untargeted MS-based metabolomics revealed microbial metabolites from P that may be responsible for these health benefits.
Topics & Concepts
DyslipidemiaFatty liverFructoseGut floraSteatohepatitisAlcoholic liver diseaseBiologyChemistryFood scienceBiochemistryPharmacologyDiseaseMedicineInternal medicineCirrhosisSunflower and Safflower CultivationLiver Disease Diagnosis and TreatmentDiet, Metabolism, and Disease