A new alkaloid derivative from the saprophytic fungus <i>Neohelicomyces hyalosporus</i> PF11-1

Abstract

A new alkaloid, neohelicomyine A (1), along with two known alkaloids (2–3), were isolated from the fermentation of Neohelicomyces hyalosporus PF11-1. The structures of these compounds were elucidated by extensive analyses of spectroscopic methods including 1 D and 2 D NMR, HRESIMS and ECD. The bioactivities of all compounds were evaluated using cellular assays, and compounds 2 and 3 displayed moderate cytotoxicities against human cancer (A549, TCA, RD) cells with IC50 values of 26–87 μg/mL.

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