Outer membrane vesicles produced by pathogenic strains of <i>Escherichia coli</i> block autophagic flux and exacerbate inflammasome activation
Laure David, Frédéric Taïeb, Marie Pénary, Pierre‐Jean Bordignon, Rémi Planès, Salimata Bagayoko, Valérie Duplan-Eche, Étienne Meunier, Éric Oswald
Abstract
GSDMD: gasdermin DGFP: green fluorescent proteinHBSS: Hanks' balanced salt solutionHlyF: hemolysin FIL1B/IL-1B: interleukin 1 betaISX: ImageStreamX systemLPS: lipopolysaccharideMut: mutatedOMV: outer membrane vesicleRFP: red fluorescent proteinTEM: transmission electron microscopyWT: wild-type.
Topics & Concepts
BiologyAutophagyInflammasomeFlux (metallurgy)Escherichia coliVesicleCell biologyMicrobiologyBacterial outer membranePathogenic Escherichia coliEscherichia coli ProteinsMembraneBiochemistryApoptosisGeneChemistryReceptorOrganic chemistryInflammasome and immune disordersBacterial Infections and VaccinesAutophagy in Disease and Therapy