Human γδ T cells recognize CD1b by two distinct mechanisms
Josephine F. Reijneveld, Tonatiuh A. Ocampo, Adam Shahine, Benjamin S. Gully, Pierre Vantourout, Adrian Hayday, Jamie Rossjohn, D. Branch Moody, Ildiko Van Rhijn
Abstract
Significance γδ T cells are an abundant component of the human immune system that protect against infection and cancer. Here we show that γδ T cells recognize CD1b proteins, which are known for their capacity to present lipid antigens to αβ T cells. Recognition of CD1b is dependent on the presented lipid antigen for some γδ T cells, but a lipid-independent pattern was also observed. Thus, γδ T cells show diversity in the type of protein recognized as well as differing surfaces of the protein.
Topics & Concepts
AntigenBiologyImmune systemCell biologyImmunologyImmune Cell Function and InteractionT-cell and B-cell ImmunologyImmune Response and Inflammation