Engineering site-selective incorporation of fluorine into polyketides
Sasilada Sirirungruang, Omer Ad, Thomas M. Privalsky, Swetha Ramesh, Joel L. Sax, Hongjun Dong, Edward E. K. Baidoo, Bashar Amer, Chaitan Khosla, Michelle C. Y. Chang
Topics & Concepts
FluorineCombinatorial chemistryChemistryDrug discoveryEscherichia coliAcyltransferaseSmall moleculeMetabolic engineeringSynthetic biologyComputational biologyBiochemistryOrganic chemistryBiologyEnzymeGeneMicrobial Natural Products and BiosynthesisCarbohydrate Chemistry and SynthesisGlycosylation and Glycoproteins Research