eIF2α incites photoreceptor cell and retina damage by all-trans-retinal
Danxue He, Lei Tao, Binxiang Cai, Xiangjun Chen, Yan Wang, Shiying Li, Chunyan Liao, Yuling Chen, Jingmeng Chen, Zuguo Liu, Yalin Wu
Abstract
mice upon light exposure. The results of this study suggest that eIF2α is an important target to develop drug therapies for the treatment of dry AMD and STGD1.
Topics & Concepts
Cell biologyIntegrated stress responseBiologyRetinaRetinal degenerationUnfolded protein responseATF4Transcription factorSignal transductionEndoplasmic reticulumBiochemistryNeuroscienceTranslation (biology)GeneMessenger RNAEndoplasmic Reticulum Stress and DiseaseRNA regulation and diseaseRetinal Development and Disorders