Transcriptomic responses are sex-dependent in the skeletal muscle and liver in offspring of obese mice
Amy C. Kelly, Fredrick J. Rosario, Jeannie Chan, Laura A. Cox, Theresa L. Powell, Thomas Jansson
Abstract
Transcriptomic data support that fetuses of obese mothers modulate metabolism in both muscle and liver. These changes were strikingly sexually dimorphic in agreement with published findings that male offspring of obese dams exhibit pronounced metabolic disease earlier. In both males and females, the transcriptomic responses in the fetus were different than those at 3 mo, implicating adaptive mechanisms throughout adulthood.
Topics & Concepts
OffspringEndocrinologyInternal medicineBiologyTranscriptomeSkeletal muscleInsulin resistanceSteatosisNonalcoholic fatty liver diseaseFatty liverPregnancyInsulinGene expressionMedicineGeneGeneticsDiseaseBirth, Development, and HealthAdipose Tissue and MetabolismGestational Diabetes Research and Management