Puerarin suppresses macrophage M1 polarization to alleviate renal inflammatory injury through antagonizing TLR4/MyD88-mediated NF-κB p65 and JNK/FoxO1 activation
Zujian Hu, Dong Chen, Penghua Yan, Zheng Fan, Hengyue Zhu, Ziwei Yuan, Xuejia Yang, Yidan Zuo, Chaosheng Chen, Hong Lu, Lianfeng Wu, Jianxin Lyu, Yongheng Bai
Topics & Concepts
PuerarinTLR4PharmacologyInflammationFOXO1Proinflammatory cytokineNF-κBDownregulation and upregulationSignal transductionAcute kidney injuryChemistryCancer researchMedicineImmunologyProtein kinase BInternal medicineBiochemistryPathologyAlternative medicineGeneChronic Kidney Disease and DiabetesPhytoestrogen effects and researchImmune cells in cancer