Targeting YTHDF1 effectively re-sensitizes cisplatin-resistant colon cancer cells by modulating GLS-mediated glutamine metabolism
Ping Chen, Xi-qiao Liu, Xiang Lin, Liying Gao, Shuo Zhang, Xuan Huang
Abstract
xenograft mouse model. In summary, our study reveals a new mechanism for YTHDF1-promoted cisplatin resistance, contributing to overcoming chemoresistant colon cancers.
Topics & Concepts
CisplatinGlutamineMetabolismColorectal cancerCancer researchCancerCancer cellChemistryMedicineOncologyInternal medicineBiochemistryChemotherapyAmino acidFolate and B Vitamins ResearchCancer, Hypoxia, and MetabolismBiochemical and Molecular Research