Cortical bone stem cells modify cardiac inflammation after myocardial infarction by inducing a novel macrophage phenotype
Alexander R. H. Hobby, Remus M. Berretta, Deborah Eaton, Hajime Kubo, Eric Feldsott, Yijun Yang, Alaina L. Headrick, Keith A. Koch, Marcello Rubino, Justin Kurian, Mohsin Khan, Yinfei Tan, Sadia Mohsin, Stefania Gallucci, Timothy A. McKinsey, Steven R. Houser
Abstract
Cortical bone stem cell (CBSC) therapy after myocardial infarction alters the inflammatory response to cardiac injury. We found that cortical bone stem cell therapy induces a unique macrophage phenotype in vitro and can modulate macrophage/fibroblast cross talk.
Topics & Concepts
InflammationPhenotypeStem cellMacrophageMyocardial infarctionMedicineInternal medicineCardiologyNeurosciencePathologyBiologyCell biologyIn vitroGeneBiochemistryCardiac Fibrosis and RemodelingMacrophage Migration Inhibitory FactorCardiac and Coronary Surgery Techniques