Tdp1 protects from topoisomerase 1–mediated chromosomal breaks in adult zebrafish but is dispensable during larval development
Ringaile Zaksauskaite, Ruth Thomas, Fredericus J. M. van Eeden, Sherif F. El‐Khamisy
Abstract
) as putative players fulfilling this role. It highlights the requirement of distinct DNA repair factors across the life span of vertebrates.
Topics & Concepts
ZebrafishBiologyCell biologyDNA damageTopoisomeraseDNA repairDNAPhosphodiesteraseGeneticsMolecular biologyGeneEnzymeBiochemistryCancer therapeutics and mechanismsDNA Repair MechanismsAntibiotic Resistance in Bacteria