<i>In Vitro</i> Activity of Gepotidacin against Gram-Negative and Gram-Positive Anaerobes
Meredith Hackel, James A. Karlowsky, Michele A. Canino, Daniel F. Sahm, Nicole E. Scangarella-Oman
Abstract
Gepotidacin (formerly GSK2140944) is a first-in-class triazaacenaphthylene antibacterial currently in phase III clinical trials. When tested against Gram-negative ( n = 333) and Gram-positive ( n = 225) anaerobes by agar dilution, gepotidacin inhibited 90% of isolates at concentrations of 4 and 2 μg/mL, respectively.
Topics & Concepts
GramMicrobiologyAgar dilutionAnaerobic exerciseGram-negative bacteriaGram-positive bacteriaIn vitroBiologyAntibacterial activityAgar Dilution MethodAgarBacteriaAnaerobic bacteriaAntibioticsMinimum inhibitory concentrationEscherichia coliBiochemistryPhysiologyGeneticsGeneCancer therapeutics and mechanismsAntibiotic Resistance in BacteriaNeutropenia and Cancer Infections