T<sub>2</sub>-FLAIR Mismatch Sign Is Caused by Long T<sub>1</sub> and T<sub>2</sub> of <i>IDH</i>-mutant, 1p19q Non-codeleted Astrocytoma
Manabu Kinoshita, Masato Uchikoshi, Mio Sakai, Yonehiro Kanemura, Haruhiko Kishima, Katsuyuki Nakanishi
Abstract
T2-fluid-attenuated inversion recovery images (FLAIR) mismatch sign is now known to be a specific yet insensitive image feature for IDH-mutant, 1p19q non-codeleted astrocytoma. The current study revealed that lesion presenting T2-FLAIR mismatch exhibited extremely long T1- and T2-relaxation time while T2-FLAIR matched lesions showed low to moderate values. On the other hand, IDH-wildtype tumors presented noticeably short T1- and T2-relaxation time. These different relaxation time characteristics seemed to render T2-FLAIR mismatch sign of becoming such a unique and specific image feature for IDH-mutant, 1p19q non-codeleted astrocytoma.
Topics & Concepts
Fluid-attenuated inversion recoveryMedicineNuclear medicineAstrocytomaSign (mathematics)Nuclear magnetic resonanceMagnetic resonance imagingRadiologyGliomaPhysicsCancer researchMathematicsMathematical analysisGlioma Diagnosis and TreatmentVascular Malformations Diagnosis and TreatmentMedical Imaging Techniques and Applications