Targeted Elimination of blaNDM-5 Gene in Escherichia coli by Conjugative CRISPR-Cas9 System
Peisi Li, Peng Wan, Ruonan Zhao, Jin Chen, Xiaoshen Li, Jie Li, Wenguang Xiong, Zhenling Zeng
Abstract
Purpose: ). Methods: J53. Results: J53 strain containing plasmid pCas9-N reduced the number of transconjugants by 26-fold. Conclusion: gene among clinical pathogens.
Topics & Concepts
CRISPREscherichia coliCas9GeneBiologyGeneticsComputational biologyCRISPR and Genetic EngineeringRNA and protein synthesis mechanismsBacterial Genetics and Biotechnology