Predicting Confined 1D Cell Migration from Parameters Calibrated to a 2D Motor-Clutch Model
L. Prahl, Maria R. Stanslaski, Pablo Vargas, Matthieu Piel, David J. Odde
Abstract
) and also predicted the effects of drugs targeting the motor-clutch system or cytoskeletal assembly. These results are consistent with glioma cells utilizing a motor-clutch system to migrate in confined environments.
Topics & Concepts
ClutchBiological systemChemistryBiophysicsBiologyEngineeringAutomotive engineeringCellular Mechanics and InteractionsMicrofluidic and Bio-sensing TechnologiesMicrotubule and mitosis dynamics