Dynamin controls neuropeptide secretion by organizing dense-core vesicle fusion sites
Alessandro Moro, Anne M van Nifterick, Ruud F. Toonen, Matthijs Verhage
Abstract
-ethylmaleimide-sensitive factor attachment protein) expression restored this. We conclude that mammalian dynamins organize DCV fusion sites, downstream of αSNAP, by regulating the equilibrium between fusogenic and non-fusogenic syntaxin-1 promoting its availability for SNARE (SNAP receptor) complex formation and DCV exocytosis.
Topics & Concepts
DynaminExocytosisCell biologySynaptic vesicleBiologySecretory VesicleSecretionVesicle fusionVesicleLipid bilayer fusionSynapseMunc-18MutantWild typeNeuroscienceBiochemistryEndocytosisMembraneCellGeneCellular transport and secretionCalcium signaling and nucleotide metabolismLipid Membrane Structure and Behavior