Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage
Michael H. Askenase, Brittany A. Goods, Hannah E. Beatty, Arthur F. Steinschneider, Sofia Velazquez, Artem Osherov, Margaret Landreneau, Shaina L. Carroll, Tho B. Tran, Victor Avram, Riley S. Drake, G. James Gatter, Jordan Massey, Saravanan S. Karuppagounder, Rajiv R. Ratan, Charles Matouk, Kevin N. Sheth, Wendy Ziai, Adrian Parry‐Jones, Issam A. Awad, Mario Zuccarello, Richard E. Thompson, Jesse Dawson, Daniel F. Hanley, J. Christopher Love, Alex K. Shalek, Lauren Sansing, ICHseq investigators, ICHseq Investigators, Steven J. Barrer, Larami MacKenzie, Karin Jonczak, Patricia Bussinger, Peter Nakaji, Shawn E. Wright, Norissa Honea, Ali Zomorodi, Michael L. James, Erlinda Yeh, Walter Galicich, Thomas Bergman, Kathryn A. France, James Leiphart, Swathi Ramesh, Tricia Brennan, Judy Huang, Wendy Ziai, Mirinda Anderson White, Paul J. Camarata, Michael Abraham, Jason Gorup, Ronald Reimer, William D. Freeman, Cristin Williams, Emily Edwards, Ania Pollack, John Terry, Angela Shoen, Babak S. Jahromi, Matthew B. Maas, Byron Yip, Christina Amidei, Lorenzo Muñoz, George Α. Lopez, Rebecca Holtz, Gaurav Gupta, Igor Rybinnik, Michelle Moccio, Darren Lovick, B Brion, Kelsey Titus, Jack Jallo, Fred Rincón, Kara Pigott, Laura Boyden, Jaime Dougherty, Mark R. Harrigan, David Miller, Lisa Nelson, Gregory Thompson, Ventatakrishna Rajajee, Aditya Pandey, Ron O. Ball, Andrew P. Carlson, Huy Tran, Amal Alchbli, Robert F. James, Ann Jerde, Philipp Taussky, Safdar Ansari, Crystal Neate, Julie Kay Martinez, Joshua Letsinger, Lilly Fagatele, Carol Eaquinto, Charles Matouk, Kevin N. Sheth, Lauren Sansing, Linda Ryall, Kimberly Kunze
Abstract
, which, in turn, augmented VEGF production. Our findings define the time course of myeloid activation in the human brain after ICH, revealing a conserved progression of immune responses from proinflammatory to proresolution states in humans after brain injury and identifying transcriptional programs associated with neurological recovery.