Exploring the impact of trifluoromethyl (–CF<sub>3</sub>) functional group on the anti-cancer activity of isoxazole-based molecules: design, synthesis, biological evaluation and molecular docking analysis
Paramita Pattanayak, Sripathi Nikhitha, Debojyoti Halder, Balaram Ghosh, Tanmay Chatterjee
Abstract
The effect of –CF 3 functional group on the enhancement of anti-breast cancer activity of isoxazole based molecules against MCF-7 is demonstrated.
Topics & Concepts
IsoxazoleChemistryMoleculeDocking (animal)TrifluoromethylFunctional groupRational designStereochemistryNanotechnologyMedicineMaterials scienceOrganic chemistryNursingPolymerAlkylSynthesis and Biological EvaluationClick Chemistry and ApplicationsSynthesis and biological activity