Cisplatin nanoparticles boost abscopal effect of radiation plus anti-PD1 therapy
Ying Wang, Na Shen, Yue Wang, Mo Li, Wanze Zhang, Liwen Fan, Linlin Liu, Zhaohui Tang, Xuesi Chen
Abstract
. This is the first study to show that CDDP-NPs can amplify RT-induced immune activation and break through the efficiency limitation of the RT plus anti-PD1 induced abscopal effect.
Topics & Concepts
Abscopal effectCisplatinRadiation therapyCD8ChemistryCancer researchInfiltration (HVAC)IrradiationRadiochemistryImmunotherapyChemotherapyMedicineImmune systemImmunologyInternal medicineMaterials sciencePhysicsNuclear physicsComposite materialCancer Immunotherapy and BiomarkersImmune Cell Function and InteractionImmunotherapy and Immune Responses