Role of active nanoliposomes in the surface and bulk mechanical properties of hybrid hydrogels
Rana Kadri, J. Bacharouch, Kamil Elkhoury, Ghazi Ben Messaoud, Cyril J.F. Kahn, Stéphane Desobry, Michel Linder, Ali Tamayol, Grégory Francius, João F. Mano, Laura Sánchez‐González, Elmira Arab‐Tehrany
Abstract
Nanoliposomes are widely used as delivery vehicles for active compounds. Nanoliposomes from rapeseed phospholipids were incorporated into interpenetrating polymer network hydrogels of gelatin methacryloyl and alginate. The multiscale physicochemical properties of the hydrogels are studied both on the surface and through the thickness of the 3D network. The obtained composite hydrogels exhibited strong mechanical properties and a highly porous surface. The blend ratio, as well as the concentration of nanoliposomes, affects the properties of the hydrogels. Nanofunctionalized hydrogels induced keratinocyte growth. These advantageous characteristics may open up many applications of the developed hydrogels in drug delivery and tissue engineering.