Recent advances in stimuli-responsive polymeric carriers for controllable CRISPR/Cas9 gene editing system delivery
Panqin Ma, Qi Wang, Xi Luo, Liuzhou Mao, Zhanxiang Wang, Enyi Ye, Xian Jun Loh, Zibiao Li, Yun‐Long Wu
Abstract
, pH, redox, or enzymes) towards controllable CRISPR/Cas9 genome editing system delivery as well as the advances in using stimulus-responsive CRISPR/Cas9 polymeric carriers towards cancer treatment. Last but not least, the key challenges and promising development strategies of stimulus-responsive polymeric vector designs for CRISPR/Cas9 systems will also be discussed.
Topics & Concepts
CRISPRGenome editingCas9Gene deliveryComputational biologyViral vectorNanotechnologyComputer scienceGenetic enhancementBiologyGeneMaterials scienceRecombinant DNAGeneticsCRISPR and Genetic EngineeringRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniques