The biphasic role of Hspb1 on ferroptotic cell death in Parkinson's disease
Jieyi Meng, Jinyu Fang, Yutong Bao, Huizhu Chen, Xiaodan Hu, Ziyuan Wang, Man Li, Quancheng Cheng, Yaqiong Dong, Xiaoda Yang, Yushu Zou, Dongyu Zhao, Jiping Tang, Weiguang Zhang, Chunhua Chen
Abstract
: These findings highlight a biphasic role of Hspb1 in PD, where it initially provides neuroprotection through the Nrf2-Hspb1 pathway but ultimately contributes to neurodegeneration and inflammation when overexpressed. Understanding this dual role is crucial for developing therapeutic strategies targeting Hspb1 and Nrf2 in PD.
Topics & Concepts
Programmed cell deathDiseaseCellParkinson's diseaseChemistryMedicineCancer researchApoptosisPathologyBiochemistryIron Metabolism and Disorders