Genotoxicity evaluation of ten nitrosamine drug substance-related impurities using 2D and 3D HepaRG cell models
Ji-Eun Seo, Hannah Xu, Xilin Li, Aisar Atrakchi, Timothy J. McGovern, Karen L Davis Bruno, David A. Keire, Nan Mei, Robert H. Heflich, Xiaoqing Guo
Topics & Concepts
GenotoxicityChemistryNitrosaminePharmacologyCarcinogenBiochemistryToxicityMedicineOrganic chemistryCarcinogens and Genotoxicity AssessmentSulfur Compounds in BiologyPolyamine Metabolism and Applications