Synthesis and biological evaluation of halogenated phenoxychalcones and their corresponding pyrazolines as cytotoxic agents in human breast cancer
Peter A. Halim, Rasha A. Hassan, Khaled O. Mohamed, Soha Osama Hassanin, Mona G. Khalil, Amr M. Abdou, Eman O. Osman
Abstract
interact with p38alpha MAPK active sites.
Topics & Concepts
Cytotoxic T cellMCF-7StaurosporineApoptosisChemistryChalconeMAPK/ERK pathwayKinaseCytotoxicityCell cultureCell growthIC50Cancer cellMitogen-activated protein kinaseProtein kinase ABiochemistryStereochemistryCancerBiologyIn vitroHuman breastInternal medicineMedicineGeneticsSynthesis and biological activitySynthesis of Organic CompoundsBioactive Compounds and Antitumor Agents