Antimicrobial peptide immobilization on catechol-functionalized PCL/alginate wet-spun fibers to combat surgical site infection
Taufiq Hasan Aneem, Mridul Sarker, Siew Yee Wong, Sierin Lim, Xu Li, Asif Rashed, Saumitra Chakravarty, M. Tarik Arafat
Abstract
spp., a pathogenic bacterium for at least 60 hours whereas antibiotic ceftazidime failed. When subjected to a linear incisional wound model study, accelerated healing was observed when the wound was closed using the engineered fiber compared to Vicryl. The microfibers promoted faster re-epithelialization compared to Vicryl proving their higher wound healing capacity.
Topics & Concepts
CatecholAntimicrobialPeptideMaterials scienceSurgical site infectionMicrobiologyChemical engineeringChemistryMedicineBiochemistrySurgeryBiologyEngineeringSilk-based biomaterials and applicationsNanoplatforms for cancer theranosticsPolydiacetylene-based materials and applications