Atom and step economical synthesis of acyclic quaternary centers <i>via</i> iridium-catalyzed hydroarylative cross-coupling of 1,1-disubstituted alkenes
Phillippa Cooper, Andrew G. Dalling, Elliot H. E. Farrar, Timothy P. Aldhous, Simon Grélaud, Eleanor Lester, Lyman J. Feron, Paul D. Kemmitt, Matthew N. Grayson, John F. Bower
Abstract
predistortion of the reacting intermediate. The key insight disclosed here will underpin the ongoing development of increasingly sophisticated branch selective Murai hydroarylations.
Topics & Concepts
IridiumIntermolecular forceCatalysisAtom (system on chip)ChemistryCoupling (piping)QuaternaryCombinatorial chemistryAtom economyMoleculeOrganic chemistryMaterials scienceComputer scienceParallel computingBiologyPaleontologyMetallurgyCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsAsymmetric Hydrogenation and Catalysis