Suboptimal moxifloxacin and levofloxacin drug exposure during treatment of patients with multidrug-resistant tuberculosis: results from a prospective study in China
Lina Davies Forsman, Katarina Niward, Johanna Kuhlin, Xubin Zheng, Rongrong Zheng, Ke Ran, Hong Chao, Jim Werngren, Jakob Paues, Ulrika S. H. Simonsson, Erik Eliasson, Sven Hoffner, Biao Xu, Jan‐Willem C. Alffenaar, Thomas Schön, Yi Hu, Judith Bruchfeld
Abstract
<b>This study found target attainment of 0–55% for patients with multidrug-resistant TB using currently recommended doses of moxifloxacin (55%) and levofloxacin (0%), meaning increased doses should be considered to ensure efficacy, if safety can be assured</b> https://bit.ly/3juED6S
Topics & Concepts
LevofloxacinMoxifloxacinMedicineOfloxacinMultiple drug resistanceTuberculosisDrugInternal medicinePharmacologyDrug resistanceAntibioticsCiprofloxacinMicrobiologyPathologyBiologyTuberculosis Research and EpidemiologyAntibiotics Pharmacokinetics and EfficacyDrug Transport and Resistance Mechanisms