Drug Titration Paradox: An Emerging Concept in Clinical Pharmacology
Charles F. Minto, Talmage D. Egan, Thomas W. Schnider
Abstract
When anesthesiologists titrate doses to achieve desired effects, a titration paradox emerges, resulting in increased drug doses that correlate with decreased effect. This challenges traditional pharmacologic understanding and requires careful analysis of potential confounding factors.
Topics & Concepts
MedicineDrugPharmacologyIntensive care medicineConfoundingTitrationClinical pharmacologyInternal medicineInorganic chemistryChemistryAnesthesia and Sedative AgentsAnesthesia and Neurotoxicity ResearchIntensive Care Unit Cognitive Disorders