Indole-imidazolone derivatives as dual Mcl-1/COX-2 inhibitors: Design-oriented synthesis, molecular docking, and dynamics studies with potential anticancer and anti-inflammatory activities
Phoebe F. Lamie, Peter A. Halim, Ahmed M. Sayed, Nesma M. Kahk, Marwa M. Abdelhakeem, Fatma El Zahraa Ammar Mohamed
Topics & Concepts
ChemistryDocking (animal)Indole testStereochemistryMolecular dynamicsPharmacologyCombinatorial chemistryComputational chemistryMedicineNursingSynthesis and Reactions of Organic CompoundsSynthesis and biological activitySynthesis of heterocyclic compounds