Design, synthesis, and biological evaluation of Wee1 kinase degraders
Shulei Zhu, Jieyu Liu, Donghuai Xiao, Peipei Wang, Jingkun Ma, Xiaobei Hu, Jingfeng Fu, Yubo Zhou, Jia Li, Wei Lü
Topics & Concepts
Wee1ChemistryIn vivoCell cycleCell cycle checkpointProteasomeApoptosisCell growthCancer researchCell biologyBiochemistryCyclin-dependent kinase 1BiologyBiotechnologyProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysMultiple Myeloma Research and Treatments