[Overexpression of NAT10 induced platinum drugs resistance in breast cancer cell].
Peng Qi, Y K Chen, Rao Cui, R J Heng, Shixin Xu, Xiaoying He, A M Yue, Jia Kang, H H Li, Yingying Zhu, Chengmiao Wang, Yuh‐Lien Chen, K Hu, Yanyan Yin, L X Xuan, Y Song
Abstract
NAT10 overexpression enhances the binding of NAT10 to PARP1 and promotes the acetylation of PARP1, which in turn prolongs the half-life of PARP1, thus enhancing PARP1 recruitment of DNA damage repair related proteins to the damage sites, promoting DNA damage repair and ultimately the survival of breast cancer cells.
Topics & Concepts
Gene knockdownTransfectionBiologyPARP1ApoptosisFlow cytometryImmunostainingImmunoprecipitationCancer researchMolecular biologyCell cultureImmunologyPoly ADP ribose polymeraseImmunohistochemistryBiochemistryDNAGeneticsPolymeraseRNA modifications and cancerCancer-related Molecular PathwaysLung Cancer Treatments and Mutations