Aryl C(sp<sup>2</sup>)–X Coupling (X = C, N, O, Cl) and Facile Control of N-Mono- and N,N-Diarylation of Primary Alkylamines at a Pt(IV) Center
Xiaoxi Lin, Arkadi Vigalok, Andrei N. Vedernikov
Abstract
N, respectively. This method allows for a one-pot preparation of diarylalkylamine bearing different aryl groups. These findings were also applied in unprecedented mono- and di-N-arylation of amino acid derivatives (lysine and tryptophan) under very mild conditions.
Topics & Concepts
ChemistryArylTrimethylsilylDenticityLigand (biochemistry)Medicinal chemistryReductive eliminationStereochemistryDensity functional theoryCrystallographyComputational chemistryCatalysisCrystal structureOrganic chemistryReceptorAlkylBiochemistryCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsFluorine in Organic Chemistry