Thioredoxin-Interacting Protein (TXNIP) Regulates Parkin/PINK1-mediated Mitophagy in Dopaminergic Neurons Under High-glucose Conditions: Implications for Molecular Links Between Parkinson’s Disease and Diabetes
Cunjin Su, Zhu Shen, Ru-Xiao Cui, Ya Huang, Delai Xu, Fenglun Zhao, Jie Pan, Aiming Shi, Tong Liu, Yunli Yu
Topics & Concepts
TXNIPMitophagyParkinPINK1Thioredoxin-Interacting ProteinSequestosome 1Cell biologyDownregulation and upregulationGene knockdownMitochondrionBiologyAutophagyChemistryThioredoxinCancer researchEndocrinologyInternal medicineMedicineOxidative stressParkinson's diseaseApoptosisBiochemistryDiseaseGeneParkinson's Disease Mechanisms and TreatmentsAutophagy in Disease and TherapyEndoplasmic Reticulum Stress and Disease