Early Use of Sarilumab in Patients Hospitalized with COVID-19 Pneumonia and Features of Systemic Inflammation: the SARICOR Randomized Clinical Trial
Nicolás Merchante, Sheila Cárcel, José Carlos Garrido-Gracia, Marta Trigo-Rodríguez, María Ángeles Esteban Moreno, Rafael León-López, Reinaldo Espíndola-Gómez, Eduardo Aguilar Alonso, David Vinuesa García, Alberto Romero-Palacios, Inés Pérez-Camacho, Belén Gutiérrez-Gutiérrez, Francisco Javier Martínez-Marcos, Concepción Fernández-Roldán, Pedro María Martínez Pérez-Crespo, Alexandra Aceituno Caño, Eva León, Juan E. Corzo, Carmen de la Fuente, Julián Torre-Cisneros
Abstract
= 0.079, log-rank test for comparisons with the control group). In patients recently hospitalized with COVID-19 pneumonia and features of systemic inflammation, early IL-6 blockade with a single dose of sarilumab 400 mg was safe and associated with a trend for better outcomes. (This study has been registered at ClinicalTrials.gov under identifier NCT04357860.).