Role of oxidative stress in induction of trans-differentiation of neutrophils in patients with rheumatoid arthritis
Aniruddha Bagchi, Parasar Ghosh, Alakendu Ghosh, Mitali Chatterjee
Abstract
functional assay validated that oxidative stress supported trans-differentiation and could be attenuated by a free radical scavenger. Taken together, the pro-inflammatory microenvironment in the SF of patients with RA coupled with a higher generation of ROS promoted the trans-differentiation of neutrophils into N-DCs, suggesting the inclusion of anti-oxidants as an add-on therapeutic strategy to limit trans-differentiation.
Topics & Concepts
ImmunologyOxidative stressCD80ChemokineReactive oxygen speciesCD86ChemistryInflammationRheumatoid arthritisArthritisCD40T cellMedicineImmune systemCytotoxic T cellBiochemistryIn vitroRheumatoid Arthritis Research and TherapiesT-cell and B-cell ImmunologyImmunotherapy and Immune Responses